第二届浙江大学-新加坡国立大学生物医学联合系列讲座

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Meeting Schedule

Keynote Speakers

A/Prof Paul MACARY

DIRECTOR LIFE SCIENCES INSTITUTE & CHAIRMAN CREATE-HUJ CONSORTIUM, DEPARTMENT OF MICROBIOLOGY & IMMUNOLOGY，NATIONAL UN/VERSITY OF SINGAPORE

Research Interests

Immune repertoires, Antibody technology, Infectious diseases. The MacAry laboratory covers a broad spectrum of antibody-related scientific endeavour, from basic B-cell research to industrial applications with an emphasis on antibody biology, immune repertoire mapping and protein engineering. In his presentation, he will detail their recent findings on the form and functionality of T-lymphocyte and Antibody responses in patients infected with or recovered from Dengue Virus.

Representative publications over the past 5 years

1. Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA*. Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01. Nature Communications. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1. (* Corresponding author)

2. Zhao X, Sankaran S, Yap JW, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti, A, MacAry PA, Brzostek J, Gascoigne NRJ. Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Zhao-X et al. Nature Communications. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.

3. Chan, JHS; Chua, YL, Peh, HY, Jovanovic, V, Gascoigne, NRJ, Wong, WSF, Chew, FT, Hanson, BJ , Kemeny, DM, MacAry, PA*. Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma. Chan et al. Journal of Allergy and Clinical Immunology. May;139(5):1705-1708. (* Corresponding author)  

4. Lai JY, Tan WJ, Too CT, Choo JAL, Wong LH , Mustafa FB, Srinivasan N, Lim APC, Zhong YJ, Gascoigne NRJ, Hanson BJ, Chan SH, Chen JZ, MacAry PA*. Targeting Epstein-Barr virus transformed B lymphoblastoid cells using antibodies with T cell receptor-like specificities. Lai J et al. Blood. 2016 Jun 23. (* Corresponding author)  

5. Rivino L, Kumaran EA, Thein TL, Too CT, Gan VCH, Hanson BJ, Wilder-Smith A, Bertoletti A , Gascoigne NRJ, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA. Virus-specific T lymphocytes home to the skin during natural dengue infection.Rivino L et al. Science Translational Medicine. 2015 Mar 11;7(278):278ra35.

Prof WANG Di

VICE DEAN, SCHOOL OF BASIC MEDICAL SCIENCES, EXECUTIVE DIRECTOR, RESEARCH CENTRE OF INFECTIONS & IMMUNITY, ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE

Research Interests

The major focus of Prof. Di Wang's group is to provide a molecular understanding of immunity and inflammation. They are interested in receptors involved in innate immunity, such as Nod-like receptors (NLRs - including Nlrp3), and also metabolic signals activated. The role played by this system in inflammatory diseases is also under investigation. Meanwhile, they are also interested in the activation and differentiation of immune cells by diverse metabolic mediators and metabolites.

Representative publications over the past 5 years

1. Zhexu Chi, Sheng Chen, Ting Xu, Wenxuan Zhen, Weiwei Yu, Fan Yang, Xue Zhang, Di Wang*. Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation. Molecular Cell. 2020 (* Corresponding author)

2. Weiwei Yu, Zhen Wang, Kailian Zhang, Zhexu Chi, Ting Xu, Danlu Jiang, Sheng Chen, Wenxin Li, Xuyan Yang, Xue Zhang, Yingliang Wu*, and Di Wang*. One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages. Molecular Cell. 2019, 75:1147-1160 (* Corresponding author)

3. Chuansheng Guo, Zhexu Chi, Danlu Jiang, Ting Xu, Weiwei Yu, Zhen Wang, Sheng Chen, Li Zhang, Qianyun Liu, Xingchen Guo, Xue Zhang, Wenxin Li, Linrong Lu, Yingliang Wu, Bao-Liang Song, and Di Wang*. Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. Immunity. 2018, 49:1-15 (* Corresponding author)

4. Chuansheng Guo, Shujun Xie, Zhexu Chi, Jinhua Zhang, Yangyang Liu, Li Zhang, Mingzhu Zheng, Xue Zhang, Dajing Xia, Yuehai Ke, Linrong Lu, and Di Wang*. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity. 2016, 45:802-816 (* Corresponding author)

5. Di Wang*, Mingzhu Zheng, Yuanjun Qiu, Chuansheng Guo, Jian Ji, Lei Lei, Xue Zhang, Xuetao Cao, Yi Ting Zhou, and Linrong Lu*. Tespa1 negatively regulates FceRI-mediated signaling and the mast cell-mediated allergic response. The Journal of Experimental Medicine. 2014, 211(13):2635-2649 (* Co-corresponding authors)

Prof Nicholas GASCOIGNE

DEPARTMENT OF MICROBIOLOGY & IMMUNOLOGY, NATIONAL UNIVERSITY OF SINGAPORE

Research Interests

Prof. Nicholas Gascoigne has established himself as a leading researcher in cellular and molecular immunology, focusing on the regulation of signalling in T cell activation and development. His lab demonstrated the role of TCR binding strength in thymocyte differentiation, and the importance of CDR1 and 2 TCR sequences in MHC restriction. They developed FRET imaging to analyze interactions between cell surface molecules, particularly TCR and coreceptors, showing that the close apposition of TCR and coreceptor required antigen recognition. In a series of papers from 2005 on, his lab demonstrated the importance of coagonism in CD8 T cell responses to antigen. His lab was one of several to identify and characterize Themis, a protein that controls thymocyte positive selection through regulation of TCR signaling strength. He maintains his interests in T cell signalling, activation, and development, including signal pathways in CAR T cells.

Representative publications over the past 5 years

1. Balyan, R., Brzostek, J., & Gascoigne, N. R. J*. (2018). CD8(+) T cells have commitment issues. Nature Immunology, 19(8), 797-799. doi:10.1038/s41590-018-0169-0. (* Corresponding author)

2. Zhao, X., Sankaran, S., Yap, J., Too C.T., Ho, Z.Z., Ren, E.C., Bertoletti, A., MacAry, P.A., Brzostek, J., and Gascoigne, N.R.J*. (2018). Non-stimulatory peptide-MHC enhances human T cell antigen-specific responses by amplifying proximal TCR signaling strength. Nature Communications. 9: 2716 (* Corresponding author)

3. Chen, E. W., Brzostek, J., Gascoigne, N. R. J. *, & Rybakin, V*. (2018). Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Scientific Reports, 8, 9 pages. doi:10.1038/s41598-018-28106-5. (* Corresponding author)

4. Mehta, M., Brzostek, J., Chen, E.W., Tung, D.W.H., Chen, S., Sankaran, S., Yap, J., Rybakin, V., and Gascoigne, N.R.J.* (2018). Themis-associated phosphatase activity controls signaling in T cell development. Proceeding of the National Academy of Sciences of the United States of America. 115: E11331-E11340 (* Corresponding author)

5. Gautam, N., Sankaran, S., Yason, J. A., Tan, K. S. W., & Gascoigne, N. R. J. * (2018). A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization. METHODS, 134, 11-19. doi:10.1016/j.ymeth.2017.11.015. (* Corresponding author)